Now, a scientific team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) and the Universite Libre de Bruxelles, has discovered a genetic explanation -- with evolutionary roots -- for the higher incidence of kidney disease among African Americans.
As reported in the July 15 online issue of the journal Science, the study found that patients with focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) harbored variants in the APOL1 gene that changed the APOL1 protein sequence. These variants are commonly found in individuals of recent African ancestry.
Furthermore, in a twist of evolutionary medicine, the disease-causing variants may have protected Africans against a lethal parasite, explaining why these genetic variants are so common in the population today.
As reported in the July 15 online issue of the journal Science, the study found that patients with focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) harbored variants in the APOL1 gene that changed the APOL1 protein sequence. These variants are commonly found in individuals of recent African ancestry.
Furthermore, in a twist of evolutionary medicine, the disease-causing variants may have protected Africans against a lethal parasite, explaining why these genetic variants are so common in the population today.
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